Ge Healthcare As

Ge Healthcare Limited

Svein Kvaale

Ole Johannes Tokerud

Torild Wickstrom

Dirk-Jan In T Veld

Carl Peter Tonseth

Thor Audun Saga

The present invention relates to a process for preparation of a composition comprising gas microbubbles. More particularly the invention relates to a process for filling of such composition into a container. The composition prepared is preferably an ultrasound contrast media composition made available in a container wherein the headspace of the container comprises the same gas as the gas of the microbubbles.

Method for filling a container with a foamable composition

A process for preparing a composition comprising encapsulated gas microbubbles, the process comprising: providing an aqueous protein solution of a heat-denaturable protein at a temperature necessary to achieve incipient denaturation; heating a gas by using heat from the heated protein solution; mixing the heated gas and the heated protein solution to obtain a gas/liquid mixture; and dispersing the gas into the protein solution by subjecting the gas/liquid mixture to mechanical shear forces to form a composition of gas microbubbles encapsulated by denatured protein.

Preparation of composition comprising gas microbubbles

The invention relates to a method for improving stability of radiopharmaceutical precursors, and in particular non radiolabelled nucleoside derivatives which are used as precursors for production of radiolabelled nucleoside derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The invention further includes formulations of radiopharmaceutical precursors, and cassettes for automated synthesis apparatus comprising the same.

Stabilisation of radiopharmaceutical precursors

A spike for penetrating the elastomeric stopper of a container, for example a drug or reagent vial, is provided with an elongated body () with a blunt tip (). The spike may be incorporated into a reagent cassette which accepts containers sealed with a punturable cap.

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Oslo, Norway

Svein Kvaale