Centre National De La Recherche Scientifique

Idenix Pharmaceuticals, Inc.

Universitè De Montpellier

L'université Montpellier Ii

Universite Claude Bernard – Lyon1

Ecole Normale Superieure De Lyon

Hospices Civils De Lyon

Université Montpellier 2 Sciences Et Techniques

Ecole Nationale Superieure De Chimie De Montpellier

Les Hospices Civils De Lyon

Université De Montpellier 1

Suzanne Peyrottes

Christian Perigaud

Jean-Pierre Sommadossi

Gilles J Gosselin

Claire Pierra

Céline Crauste

Charles Dumontet

Sharon Wein-Grataud

Isabelle Krimm

Lars Petter Jordheim

Remi Guillon

David Egron

Zsuzsanna Marton

Corinne Lionne

Laurent Chaloin

Rémi Guillon

Chemical compounds are provided belonging to the group of nucleotide analogues. More specifically, acylnucleoside phosphonate compounds are disclosed and also their method of preparation and their use as medicaments, in particular for the prevention and/or the treatment of diseases caused by infection by an organism that is auxotrophic for purines, such as. Also disclosed are pharmaceutical compositions containing such compounds.

Acylnucleoside phosphonates, prodrugs thereof and use thereof as medicament

The subject matter of the present invention is compounds which have a 6-aminopurine backbone corresponding to formula (I): in which R, R, R, X, Y and Z are as defined in any one of claimsto, and Ar is a biphenyl or a naphthyl which may be substituted with R, for use in the treatment of cancer. 

5'-nucleotidase inhibitors and therapeutic uses thereof

Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

Compounds and pharmaceutical compositions for the treatment of viral infections

The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.

Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared

Growing community of inventors

Grabels, France

Suzanne Peyrottes