New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery

New York Society for the Relief of the Ruptured and Crippled, Maintaining the Hospital for Special Surgery

Hospital for Special Surgery

The Texas A&m University System

Princeton University

Suzanne Maher

Russell F Warren

Tony Chen

Scott Rodeo

Hongsheng Wang

Joseph David Lipman

Matthew F Koff

Hollis Potter

Peter Torzilli

Mario Lustri

Jeffrey J Schwartz

Brooke Hageman Russell

Casey Marie Jones

Kenneth Ng

Florian Wanivenhaus

Axel Oscar Magnus Hook

A system that includes: a force sensor assembly adapted to monitor a load as applied on a subject's knee joint when the force sensor assembly remains in direct contact with the subject's lower extremity and the load is monitored from inside a main magnet of an MRI scanner; a mobile unit comprising tracks configured to adjust a position of the force sensor assembly; a stationary base on which the mobile unit and the force sensor assembly are located, the mobile unit translatable solely axially on the stationary base; and a processor coupled to the force sensor assembly and programmed to read information encoding the load being monitored by the force sensor assembly, wherein an MRI scan of the knee joint is initiated only when a pre-determined load has been applied to the subject's knee joint for a pre-determined period of time.

System and apparatus for securing knee joint with a load for magnetic resonance imaging

An improved method of making, manufacturing and/or producing engineered orthopedic soft tissue including cartilage, meniscus, annulus fibrosus, and tendon/ligaments which results in engineered soft tissue in which the fibers are aligned the same or nearly the same as naturally occurring tissue. The present invention also includes molds and other apparatus for carrying out the methods of the invention and kits.

Method of making, manufacturing or producing orthopedic soft tissue

A method for intraoperatively measuring joint contact mechanics of a patient's joint is provided. The method includes inserting a sensor between first and second bones of a joint. Then a predetermined force is applied to one of the first and second bones. Afterwards, contact mechanics such as, contact stresses, contact areas and/or forces are measured between the first and second bones in response to the applied predetermined force.

System and method for intraoperative joint contact mechanics measurement

An improved new method of making a multi-component implant comprising a solid hydrogel, a porous hydrogel, and a porous rigid base suitable for implantation into a mammal, to treat, repair or replace defects and/or injury biological tissue as well as the implant made from the improved method. The invention also includes an improved method for making devices, constructs, and materials comprising a hydrogel and a porous rigid material. The invention also includes a mold and kits for performing the methods.

Method of and a mold for the manufacture, making and/or production of a multi-component implant, device, construct or material

An implant comprising at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered 'the hydrogel'), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.

Multi-component non-biodegradable implant, a method of making and a method of implantation

An implant having at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered 'the hydrogel'), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.

The present invention relates to a method of manufacture of an interconnected porous non-biodegradable polymer implant suitable for implantation into a mammal for the treatment, repair or replacement of defects or injury in musculoskeletal tissue, wherein the mechanical properties of the implant can be controlled by varying the concentration of the non-biodegradable polymer and/or varying the duration and number of freeze-thaw cycles and the interconnected porous non-biodegradable polymer implant has sufficient percent porosity and pore diameter to facilitate integration of cells and attachment within the mammal via ingrowth of surrounding tissue. The present invention also relates to an implant manufactured by the method.

Interconnected porous non-degradable poly(vinyl) alcohol implant and method of manufacture

The present invention relates to a novel composition comprising an implant, scaffold or construct bound to a biological or chemical moiety. The bound moiety has the ability to bind to a component of the extracellular matrix of biological tissue, allowing the implant to be bound to the biological tissue in a short period of time after implantation. The invention also relates to the use and manufacture of this novel composition, as well as a novel use for the protein CNA.

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Highland Lakes, NJ, United States of America

Suzanne Maher