Merck + Co., Inc.

Suzanne M Mandala

Robert A Giacobbe

Rosemary A Thornton

Deborah L Zink

Guy H Harris

James E Curotto

Gerald F Bills

Fernando Pelaez Perez

Angeles Cabello Arroyo

Robert E Schwartz

John R Thompson

Isabel Martin

Angeles Cabello

Isabel Martin Fernandez

Teresa Diez Matas

Francisca Vicente Perez

Evon A Bolessa

Otto D Hensens

Malcolm Maccoss

Richard L Monaghan

Fernando Pelaez

Ali Shafiee

Maria T Diez

Jon David Polishook

James D Bergstrom

William J Parsons

E Tracy Jones

Gregory L Helms

Walter Rozdilsky

Richard K Jansson

Teresa D Matas

Mark Rattray

Bruce W Burgess

Gan-Ju Maria Shei

Janet M Sigmund

Cheryl Meyers

Francisca Vincente Perez

Joan A Lasota

S Dreikorn

Wendy H Clapp-Shapiro

Mark J Rosenbach

Deborah J Card

Hugh Rosen

Rupprecht Kathleen

Richard Hajdu

Asphingosine-1-phosphate (S1P) receptor isoform 1 (cS1P), the nucleic acid encoding the cS1Preceptor, and methods for using the cS1Preceptor and the nucleic acid encoding the cS1Preceptor in assays for identifying analytes which modulate activity of the cS1Preceptor.

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The present invention provides polynucleotides and polypeptides of a human sphingosine-1-phosphate phosphatase, referred to herein as hSPP1. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probes and primers, antibodies against the hSPP1 protein and polypeptides thereof, assays for the presence or expression of hSPP1 and assays for the identification of compounds that interact with hSPP1.

Human sphingosine-1-phosphate phosphatase and inhibition methods

The present invention provides polynucleotides and polypeptides of a murine sphingosine-1-phosphate phosphatase, referred to herein as mSPP1. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probes and primers, antibodies against the mSPP1 protein and polypeptides thereof, assays for the presence or expression of mSPP1 and assays for the identification of compounds that interact with mSPP1.

Polynucleotide sequences encoding mouse sphingosine-1-phosphate phosphatase

Phosphate derivatives as immunoregulatory agents

Biotransformation products of a fermentation with Streptomyces sp., (Merck Culture Collection MA7165) ATCC No. 55946 are potent antifungal agents. These products may be useful in the treatment of diseases caused by fungal pathogens such as Candida sp. and Cryptococcus neoformans.

Microbial transformation products with antifungal properties

There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.

Antifungal agent from sporomiella minimoides

Antifungal agent

A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.

Anti-fungal agents

A compound having the formula ##STR1## which is useful as an antifungal agent and for the treatment and control of several agricultural phytopathogens, including Phytophthora infestans, is disclosed.

Compounds having the formula ##STR1## wherein R and R.sup.1 may be H or COCH.sub.3 provided that when R.sup.1 is COCH.sub.3, R is COCH.sub.3 are described.

Antibiotic agents

Growing community of inventors

Scotch Plains, NJ, United States of America

Suzanne M Mandala