National Research Council of Canada

Gilead Sciences, Inc.

Suzanne Grothe

Traian Sulea

Maureen D O'Connor-McCourt

Jason Baardsnes

Maria L Jaramillo

Myriam Banville

Renald Gilbert

Ilia Alexandre Tikhomirov

Bruno Gaillet

Maria Jaramillo

Herein described are antibodies to epidermal growth factor receptor (EGER) having an EGER binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.

Antibodies selective for cells presenting EGFR at high density

Herein described are antibodies to epidermal growth factor receptor (EGFR) having an EGFR binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.

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Montreal, Canada

Suzanne Grothe