The General Hospital Corporation

The General Hospital Corpoation

Rhode Island Hospital

Panacea Pharmaceuticals, Inc.

Jack R. Wands

Suzanne De La Monte

Mehmet Ozturk

Jerome Gross

Jack Raymond Wands

Hossein A Ghanbari

Mark Jon Olsen

Alan H Deutch

Jack R Wands

This invention relates to a method of detecting and diagnosing neurological disease or dysfunction using antibodies against a neurological form of Pancreatic Thread Protein (nPTP). Specifically, this invention is directed to a method of diagnosing Alzheimer's Disease, Down's Syndrome, and other neurological diseases or dysfunctions by using monoclonal antibodies, combination of those monoclonal antibodies or nucleic acid probes, to detect nPTP. The invention also relates to a recombinant DNA molecule encoding PTP and to the substantially pure form of nPTP. The invention additionally relates to a method of diagnosing pancreatic disease using antibodies against Pancreatic Thread Protein.

Method of detecting neurological disease or dysfunction

The present invention is directed to recombinant hosts expressing novel proteins associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. This invention is specifically directed to the recombinant hosts and vectors which contain the genes coding for the neuronal thread proteins. This invention is also directed to substantially pure neural thread protein, immunodiagnostic and molecular diagnostic methods to detect the presence of neural thread proteins, and the use of nucleic acid sequences which code for neural thread proteins in gene therapy.

Neural thread protein gene expression and detection of Alzheimer's

Neural thread protein gene expression and detection of alzheimer's

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Cambridge, MA, United States of America

Suzanne De La Monte