Microcide Pharmaceuticals, Inc.

Essential Therapeutics, Inc.

Suzanne Chamberland

Ving J Lee

Roger Leger

Zhijia J Zhang

Thomas Eric Renau

May Lee

William John Watkins

Kiyoshi Nakayama

Scott J Hecker

Olga Lomovskaya

May D Lee

Masami Ohtsuka

Toshiharu Ohta

Joaquim Trias

Yohei Ishida

The use of compounds of the milbemycin class as inhibitors of efflux pumps in microbes or other cells is described, along with pharmaceutical compositions incorporating a milbemycin. Also described is a method of screening for compounds which inhibit a CDR1, CDR2, BEN, or FLU1 efflux pump or a pump with components having a high level of protein level sequence similarity with the components of those efflux pumps.

Fungal efflux pump inhibitors

Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.

Efflux pump inhibitors

Methods are provided for screening for inhibitors of microbial efflux pumps including those which export antibiotics. The screening methods are based on the increase in the intracellular concentration of a compound, such as an antibiotic, when the bacterial cells are contacted with an efflux pump inhibitor. In addition, this invention provides pharmaceutical compositions containing such efflux pump inhibitors, and methods for treating microbial infections using those compositions.

Method for screening for non-tetracycline efflux pump inhibitors

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Los Gatos, CA, United States of America

Suzanne Chamberland