1st Biotherapeutics, Inc.

Institut Pasteur Korea

Suyeon Jo

Jinhwa Lee

Jae Eun Kim

Misoon Kim

A Yeong Park

Keonseung Lim

Seung Mook Lim

Hwajung Nam

Gadhe Changdev Gorakshnath

Yeonguk Jeon

Yejin Hwang

Inyoung Yang

Wanjun Li

Mingzhu Fan

Gwibin Lee

Minwoo Lee

Jong Yeon Hwang

Dongsik Park

Jihyun Choi

Hyeongjun Kim

Hee-Young Kim

Gyooseung Jung

Jaewon Yang

Heekyoung Yang

Jeongjin Kwon

Hyonam Kim

Jaeheon Lee

Marc P Windisch

The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method to treat or prevent inflammatory and autoimmune diseases, especially neuroinflammation diseases using the compound.

Compounds for prevention or treatment of neurodegenerative disorders

The present disclosure provides polymorphic forms and salts of (1S,2S)-2-fluoro-N-(6-(4-methylpyridin-3-yl)benzo[d]thiazol-2-yl)cyclopropane-1-carboxamide, pharmaceutical compositions comprising the compounds, processes for preparation of the compounds, and methods for treating neurodegenerative disorders.

Pharmaceutical salts of benzothiazol compounds, polymorphs and methods for preparation thereof

The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salts thereof, a composition comprising the compound, methods of using the compound for the treatment of various disorders associated with HPK1, and methods of preparing these compounds.

Substituted indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors

The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method to treat or prevent neurodegenerative diseases using the compound.

Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders

The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method for treating or preventing an inflammatory and autoimmune diseases, especially neuroinflammation diseases using the compound.

2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds

The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salts thereof, a composition comprising the compound, methods of using the compound for the treatment of various disorders associated with HPK1, and methods of preparing these compounds. 

Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same

The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method to treat or prevent neurodegenerative diseases using the compound. 

The present disclosure provides a compound of general Formula (I) having c-abl kinase inhibitory activity or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound, and a method useful to treat or prevent neurodegenerative diseases using the compound. 

Benzothiazol compounds and methods using the same for treating neurodegenerative disorders

The present disclosure provides a process for preparing (1S,2S)-2-fluoro-N-(6-(4-methylpyridin-3-yl)benzo[d]thiazol-2-yl) cyclopropanecarboxamide or a salt thereof, such as the compound of Formula (I), comprising: reacting Compound 1 as a starting material with Compound 2 in the presence of Pd(dppf)Cland 1,4-dioxane to form Compound 3; reacting Compound 3 with Compound 4 in the presence of HATU and DIPEA to produce Compound 5; and reacting Compound 5 with hydrochloric acid to produced Formula (I).

Processes for preparing benzothiazol compounds and methods of using the same for treating neurodegenerative disorders

The present invention relates to small molecule compounds and their use in the treatment of diseases, in particular viral diseases, in particular hepatitis C virus (HCV).

Growing community of inventors

Gyeonggi-do, South Korea

Suyeon Jo