Kyowa Hakko Kogyo Co., Ltd.

Susumu Tomohiro

Kenichiro Takayama

Kazuyuki Mineura

Yuko Arai

Shizuko Shirasuna

Yukoh Arai

Menaquinone-4 is produced by cultivating in culture media a microorganism belonging to the genus Corynebacterium Arthrobactor, Brevibacterium, Microbacterium, Cutobacterium, Auteobacterium or Flavobacterium which produces menaquinone-4 and recovering the same.

Process for producing menaquinone-4

A process for producing mitomycin A by fermentation, which involves culturing a microorganism belonging to the genus Streptomyces, which is capable of producing mitomycin A and having at least one property of (1) deficiency in an ability to produce mitomycin C and (2) a resistance to tryptophan analog, in a culture medium forming and accummulating mitomycin A in the culture medium; and recovering mitomycin A therefrom. The microorganism preferably involves Streptomyces caespitosus T-17-135 (NRRL 12508) or Streptomyces caespitosus (NRRL 12513).

Growing community of inventors

Shizuoka, Japan

Susumu Tomohiro