Teijin Limited

Teijin Pharma Limited

Universal Sales Co., Ltd.

Susumu Takeuchi

Naoki Hase

Yoshiyuki Matsumoto

Akinobu Maruyama

Kunio Minamizono

Naoki Tsuchiya

Yoshimasa Takahashi

Takashi Tsuruo

Minoru Imai

Takumi Takeyasu

Takao Yamori

Tomonori Yokoyama

Akinobu Nakanishi

Yoshiyuki Sawai

Takaaki Hishinuma

Hiroshi Takahashi

Gen Unoki

Tsuyoshi Mizuno

Kosuke Sasaki

Hiroshi Saitoh

Yuri Sakai

Kyohei Horie

Takuya Yokosaka

Tomohiro Shimada

Junji Igarashi

Mika Fujinuma

Masaru Ebisawa

Hirofumi Kamada

The purpose of the present invention is to provide a compound having an excellent CDK4/6 inhibiting activity. The present invention is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof. 

Pyrido[3,4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof

Provided is a novel pyrazine derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof, or a solvate thereof which is useful for treating or preventing diseases in which URAT1 is involved, including gout, hyperuricemia, hypertension, renal diseases such as interstitial nephritis and the like, diabetes, arteriosclerosis, Lesch-Nyhan syndrome, and the like.

Pyrazine derivatives

Provided is a pyridine derivative represented by formula (I), a prodrug thereof, a pharmaceutically acceptable salt of the pyridine derivative or the prodrug, or a solvate of the pyridine derivative, the prodrug or the pharmaceutically acceptable salt, which is useful for treatment or prophylaxis of diseases associated with URAT1 such as gout, hyperuricemia, hypertension, kidney diseases such as interstitial nephritis, diabetes, arteriosclerosis and Lesch-Nyhan syndrome. 

Pyridine derivative

The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides 4,4-(disubstituted)piperidine derivatives represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C-Calkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis. 

4,4-disubstituted piperidine derivatives having CCR3 antagonism

The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides compounds represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C-Calkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis. 

Piperidine derivatives having CCR3 antagonism

The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

Thiobenzimidazole derivatives

The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.&#x2003;

Anthranilic acid derivative

The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.

Anthranilic acid derivatives

A coin game machine enables a player to easily count the number of coins that are paid out from a coin pay-out hole of the coin game machine. Three rows of grooves are formed on a receiving pan of the coin game machine. The coins that are paid out from the coin pay-out hole are orderly lined up along each of the grooves . Therefore, the player can see all the coins and count the number of the coins easily. In this case, by counting in advance the number of coins that can be stored in each row of the grooves , the player can count the number of coins stored on the receiving pan further easily.

Coin receiving pan of a game machine having a tray with grooves for arranging coins

A coin game machine enables a player to easily count the number of coins 23 that are paid out from a coin pay-out hole 10 of the coin game machine. Three rows of grooves 22a are formed on a receiving pan 22 of the coin game machine. The coins 23 that are paid out from the coin pay-out hole 10 are orderly lined up along each of the grooves 22a. Therefore, the player can see all the coins 23 and count the number of the coins 23 easily. In this case, by counting in advance the number of coins that can be stored in each row of the grooves 22a, the player can count the number of coins stored on the receiving pan 22 further easily.

Game machine having groove for arranging coins

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Tokyo, Japan

Susumu Takeuchi