Shionogi Company Limited

Susumu Mitsumori

Yoshiharu Hiramatsu

Tsunetoshi Honma

Jun Sato

Hideaki Watanabe

Masanao Inagaki

Norihiko Tanimoto

Takashi Sasatani

Hiroshi Hashizume

Natsuki Ishizuka

Yasuhiko Fujii

Yoshikazu Fukui

Hiramatsu Yoshiharu

Masahide Odan

The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R, R, R, R, and G are defined as herein, a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

3-carbamoyl-2-pyridone derivatives

A compound having CRTH2 receptor antagonism, represented by the following formula (I). The compound is useful for the treatment of allergic diseases having a relation to eosinophils and the like. A compound of the formula (I): whereina group represented by the formula: is a group represented by the formula: and the like, Ris carboxy and the like, Ris &#x2014;(CH)n-N(&#x2014;Y)&#x2014;SO&#x2014;Ar and the like, the other symbols are as defined in claim

Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism

The present invention provides a process for the preparation of a bicyclic aminoalcohol which comprises reacting a starting compound, nopinone (I), with XCHCOORwherein X is halogen, and Ris alkyl, in the presence of an additive and a base to produce a compound (II), converting it to oxime derivative (III), and reducing it with an aluminum hydride 

Processes for the preparation of bicyclic aminoalcohols

The present invention provides a process for the preparation of a bicyclic aminoalcohol which comprises reacting a starting compound, nopinone (I), with XCH COOR wherein X is halogen, and R is alkyl, in the presence of an additive and a base to produce a compound (II), converting it to oxime derivative (III), and reducing it with an aluminum hydride.

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Osaka, Japan

Susumu Mitsumori