Kyorin Pharmaceutical Co., Ltd.

Kyorin Pharameuticals Co., Ltd.

Susumu Kinoshita

Masahiro Nomura

Koji Murakami

Katsuya Awano

Masaki Tsunoda

Hiroya Satoh

Toshio Maeda

Tsutomu Irikura

Hiroaki Uchida

Seigo Suzue

Kuniyoshi Masuzawa

Kyuya Okamura

Shizuyoshi Fujimori

Satoshi Murayama

Hiroshi Matsukubo

Hirotaka Shinoda

Kazunori Kasuga

The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for preparing the same, and relates to N-benzyldioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) ##STR1## [wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms, hydroxyl groups, nitro groups, amino groups which may be substituted with lower alkyl group(s) with carbon atoms of 1 to 3 or hetero rings, or R.sup.1 and R.sup.2 link to form a methylenedioxy group, R.sup.3 denotes a lower alkoxy group with carbon atoms of 1 to 3, hydroxyl group or halogen atom, and dotted line indicates double bond or single bond in combination with solid line], and processes for preparing the same.

N-benzyldioxothiazolidylbenzamide derivatives and process for producing

N-benzyldioxothiazolidylbenzamide derivatives and processes for

N-substituted dioxothiazolidylbenzamide derivatives and process for

This invention relates to a novel imidazo[1,5-a]pyrimidine derivatives and process for their preparation. Moreover, it relates to novel imidazo[1,5-a]pyrimidine derivatives and salts thereof having antifungal activities, and process for their preparation.

Imidazo [1,5-a]pyrimidine derivatives and process for their preparation

This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of formula; ##STR1## which have a potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications. The invented processes are useful as improved and convenient method for a large scale manufacture.

Process for the manufacture of spiro-linked pyrrolidine-2,5-dione

This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of the formula; ##STR1## which have a potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications. The invented processes are useful as improved and convenient method for a large scale manufacture.

Process for the manufacture of spiro-linked pyrrolidine 2,5-diones

Imidazo [1,5-a] pyrimidine derivatives of the formula (I) exhibit antifungal properties: ##STR1## wherein X.sub.1 and X.sub.2 are selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxy group, an amino or substituted amino group, an alkoxy group, an alkylthio group, an alkylsulfinyl group and an alkylsulfonyl group; R.sub.1, R.sub.2 and R.sub.3 are selected from the group consisting of a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group and an aralkyl group. Compound (I) are prepared by reacting the corresponding .alpha.-acylamino-alkylpyrimidines with condensing agents to form chlorine-substituted imidazo [1,5-a] pyrimidines, then replacing one or both chlorine atoms in the pyrimidine ring with other substituents, if necessary.

Imidazo(1,5-a)pyrimidine derivatives and their use as antimycotic agents

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Shiraoka-machi, Japan

Susumu Kinoshita