Japan Tobacco Inc.

Pfizer Corporation

Susumu Katoh

Hiroshi Kawakami

Hiroshi Ueno

Vincent Jacob Kalish

John Howard Tatlock

Susumu Miyazaki

Itsuo Uchida

Maria Angelica Linton

Wataru Watanabe

Yuji Matsuzaki

Shuichi Wamaki

Kouichi Aoyagi

Hirotaka Isoshima

Satoru Kobayashi

Kazunobu Yamataka

Tomoyuki Manabe

Shinichi Kiyonari

Kaoru Adachi

Shinsuke Sayama

Hidetsura Cho

Kazuo Aisaka

Jesus Ernesto Villafranca

Mikio Hayashi

Katsuyuki Yokota

Hiroki Tada

Shin-Ya Sasaki

Kazuhiro Tsutsumi

Takashi Shimada

The spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof 

Spiro compounds and pharmaceutical use thereof

The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor

Compounds that inhibit the peptidyl-prolyl isomerase (rotamase) enzyme activity of the FK-506 binding protein (FKBP) and compositions comprising these compounds are described. The FKBP-inhibiting compounds have a bicyclic &lsqb;3.3.1&rsqb;, &lsqb;4.3.1&rsqb; or polycyclic azaamide nucleus. Pharmaceutical compositions containing such compounds help stimulate the outgrowth of neurites in nerve cells and augmenting nerve regeneration. Methods of treating nerve cells with such compositions are useful to promote repair of neuronal damage caused by disease and physical trauma.

Compounds, pharmaceutical compositions, and methods for stimulating neuronal growth and elongation

Amidine compounds

Chroman derivative and pharmaceutical use thereof

Growing community of inventors

Osaka, Japan

Susumu Katoh