Toyo Boseki Kabushiki Kaisha

Dainippon Ink and Chemicals, Incorporated

Susumu Kashiwabara

Hidenori Tanaka

Yuta Kawakatsu

Fumihiko Kajii

Masaki Sato

Yoshiyuki Taenaka

Hisateru Takano

Masakazu Tanaka

Kazunari Sakai

Takeshi Nakatani

Ken Murayama

Masayoshi Satoh

Takashi Kimura

Michiko Suzuki

Eisaku Sasaki

Toru Takehisa

Satoru Murata

Masaki Satoh

Eisuke Tatsumi

Tomohiro Nishinaka

A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.

Method for the manufacture of nerve regeneration-inducing tube

A nerve regeneration-inducing tube is provided which is excellent in cell growth property, resistance to pressure, shape recovery property, and anti-kink property in a nerve regeneration-inducing tube where a collagen solution is applied on the outer surface of a tubular body woven with ultrafine fiber comprising biodegradable and bioabsorbable polymer while collagen is filled in the inner area of the tubular body. The nerve regeneration-inducing tube has a degradation speed which is adjusted so as to make it suitable for the connection of nerve gaps of more than 40 mm. The nerve regeneration-inducing tube includes collagen coated on the outer surface of a tubular body woven with fiber bundles where plural ultrafine fibers comprising a biodegradable and bioabsorbable polymer are bundled. The tubular body mostly comprises a first polymer which is biodegradable and bioabsorbable and a second polymer which has higher biodegradability and bioabsorbability than those of the first polymer.

Nerve regeneration-inducing tube

The present invention provides a method for coating an inner surface of a polyvinyl chloride medical tube containing a plasticizer with an antithrombogenic material composed of a specific (meth)acrylate copolymer. The simple method of the present invention is capable of evenly and efficiently coating an inner surface of a polyvinyl chloride medical tube with a sufficient amount of an antithrombogenic material without causing appearance deterioration or uneven coating due to elution of the plasticizer. The method is performed by passing through a tube a solution that is prepared by dissolving an antithrombogenic material in a solvent composed of water and at least one alcohol that is adjusted to dissolve the copolymer of the antithrombogenic material but does not dissolve the plasticizer, then subsequently passing water through the tube, and finally drying the tube.

Method for coating inner surface of medical tube made from vinyl chloride with anti-thrombotic material

The present invention provides a nerve regeneration-inducing tube in which collagen having excellent adhesive property, cell growth property and differentiation inducing property to nerve cells is used as a scaffold for the nerve regeneration. The nerve regeneration-inducing tube is characterized in using the collagen which is made the concentration of sodium chloride contained therein not more than 2.0% by weight or, preferably, 0.1 to 1.5% by weight in a dry state. Purification of collagen is carried out by means of an isoelectric precipitation where the pH is 6.0 or higher and is lower than 10.0.

[Object] An object of the present invention is to provide a surface-treating agent excellent in antithrombogenicity, and accordingly, excellent in biocompatibility, and having high hydrophilicity as compared with conventional medical materials. Further, an object of the present invention is to provide a production method excellent in performance of removing unreacted monomers and further improving a yield as compared with conventional production methods. [Constitution] The present invention relates to a water-insoluble copolymer comprising alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate. The present invention also relates to a method for producing a water-insoluble (meth)acrylate copolymer by copolymerizing alkyl(meth)acrylate and methoxypolyethylene glycol(meth)acrylate in a common polymerization solvent. Further, the present invention relates to a method for purifying (meth)acrylate copolymer by purifying (meth)acrylate copolymer by reprecipitation using a mixed solution of an alcohol having 1 to 10 carbon atoms and water.

(Meth)acrylate copolymer, a method for producing the same and a medical device

The invention provides an oxygenator of a hollow fiber membrane type where a plurality of hollow fiber membranes are received in a housing, wherein at least a part of the regions of the hollow fiber membranes to contact blood during use is coated with a water-insoluble (meth)acrylate copolymer in which a hydrophobic (meth)acrylate is copolymerized with a hydrophilic (meth)acrylate at a molar ratio of (50 to 90):(50 to 10).

Oxygenator of a hollow fiber membrane type

A membrane artificial lung performs gas exchange between blood and a gas via the membrane by flowing the blood in one side of the membrane and flowing oxygen or an oxygen-containing gas in the other side of the membrane. The membrane has a hollow fiber membrane of poly-4-methylpentene-1 and an oxygen permeation rate Q(O) at 25&#xb0; C. of from 1&#xd7;10to 3&#xd7;10(cm(STP)/cm&#xb7;sec&#xb7;cmHg) and an ethanol flux of from 0.1 to 100 ml/min&#xb7;m. The membrane has, in the side of the blood flow, a surface having an ionic complex derived from: quaternary aliphatic alkylammonium salts; and heparin or a heparin derivative. The quaternary alkylammonium salts are a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.

Artificial lung of membrane type

The present invention provides a blood-compatible composition containing an ionic complex consisting of an organic cationic compound and heparin or a derivative thereof, wherein the organic cationic compound is an ammonium or a phosophonium bound with four aliphatic alkyl groups, the four aliphatic alkyl groups having a total number of carbon atoms of 24 to 32, and has at least 2 alkyl groups having not less than 10 carbon atoms. A medical device capable of long-term sustention of antithrombogenicity can be produced by coating the surface of the medical device with the composition.

Blood-compatible composition and medical device using same

There is disclosed a draining cannula to be connected with the left atrium which comprises a tip portion (A), a curvature portion (B) connected with said tip portion and a body tubular portion (C) connected with said curvature portion. The length and the outer diameter of said cannula is sufficient for inserting the cannula into the femoral vein and for reaching the tip portion the left atrium passing through the cava, the right atrium and the interatrial septum. The portion (B) is made of a material which is more flexible than that of said portion (C). A resilient spiral thin wire is provided within the thickenss of the wall part defining the lumen of the curvature portion (B). The cannula is used for draining from the left atrium by inserting it into the femoral vein and passing the tip portion (A) of said cannula through the cava, the right atrium and the interatrial septum to reach the left atrium, without thoracotomy.

Cannula

A gas-permeable material with excellent compatibility with blood comprising polyurethane, polyurethaneurea, or the derivatives thereof is provided. The polyurethane or polyurethaneurea is obtained from a composition that comprises diisocyanate; polysiloxane containing terminal hydroxyl groups; and polyol or polyamine containing at least one tertiary amino gorup. The derivatives of the polyurethane or polyurethaneurea is obtained by the following steps of: converting the tertiary amino groups contained in the polyurethane or the polyurethaneurea to quarternary ammonium groups, and treating the polyurethane or the polyurethaneurea having quarternary ammonium groups with heparin.

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Ohtsu, Japan

Susumu Kashiwabara