Genentech, Inc.

F. Hoffmann-La Roche Ag

Sussie Lerche Krintel

Alan G Olivero

Robert Andrew Heald

Chudi Obioma Ndubaku

Timothy Heffron

Graham Elgin Jones

Lan Wang

Jennafer Dotson

Neville James McLean

Laurent Salphati

BinQing Wei

BinQuing Wei

Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions.  Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

Tricyclic PI3K inhibitor compounds and methods of use

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Harlow, United Kingdom

Sussie Lerche Krintel