University of Alberta

Other

The Royal Institution for the Advancement of Learning / Mcgill University

The Secretary of State for Environment, Food and Rural Affairs

48Hour Discovery Inc.

Susmita Sarkar

David R Bundle

Ratmir Derda

Donald Christopher Sheppard

Laurence Howells

John McGiven

Todd Lambert Lowary

Satadru Sekhar Mandal

Benjamin Alfred William Rufus Ralph

Amira Ibrahim Aly Mohamed Khalil

Lucy Duncombe

David Bundle

Nicholas Bennett

It is provided novel anti-galactofuranose antibodies and their use for diagnosis of and/or treating aspergillosis, and for the design of chimeric antigen receptor T-cells, wherein single chain variable fragment of the antibodies, such as a heavy chain variable region or a light chain variable region, is fused via a spacer and a transmembrane domain to a signaling endodomain to generate an expression cassette that will be integrated into a T cell.

Anti-galactofuranose antibodies for detecting and treating aspergillosis

There is provided a molecule comprising a chain of seven or more contiguous units of 4,6-dideoxy-4-acylamido-α-pyranose each pair of units joined by a C-Cor a C-Clink, the chain having a terminal end and a reducing end, wherein the pyranose ring in the unit of the chain most distal from the reducing end is linked to a cap structure. The cap structure is not a 4,6-dideoxy-4-acylamido-α-pyranose. There are also provided vaccine compositions comprising the molecule and methods of vaccinating an animal against infection by aorganism, including methods of distinguishing between a vaccinated and an infected animal. There are further provided novel methods of detecting the presence in a sample of an anti-antibody.

Polysaccharide and methods

There is provided a molecule comprising a chain of seven or more contiguous units of 4,6-dideoxy-4-acylamido-&#x3b1;-pyranose, each pair of units joined by a C-Cor a C-Clink, the chain having a terminal end and a reducing end, wherein the pyranose ring in the unit of the chain most distal from the reducing end is linked to a cap structure. The cap structure is not a 4,6-dideoxy-4-acylamido-&#x3b1;-pyranose. There are also provided vaccine compositions comprising the molecule and methods of vaccinating an animal NI against infection by aorganism, including methods of distinguishing between a vaccinated and an infected animal. There are further provided novel methods of detecting the presence in a sample of an anti-antibody.

Growing community of inventors

Edmonton, Canada

Susmita Sarkar