Biomay Ag

Phadia Ab

Biomay Produktions- Und Handelsaktiengesellschaft

Susanne Spitzauer

Rudolf Valenta

Paolo Colombo

Peter Valent

Ines Swoboda

Susanne Vrtala

Birgit Linhart

Margarete Focke-Tejkl

Dietrich Kraft

Wolfgang R Sperr

Hans Grönlund

Jonas Lidholm

Kerstin Westritschnig

Theresia Popow-Kraupp

Marianne Van Hage

Katharina Blatt

Pirjo Lehtonen

Sabine Stumvoll

Renate Reininger

Verena Niederberger

Asa Marknell Dewitt

Anna Gieras

Raffaela Campana

Johanna Tinhofer

Domenico Geraci

Giovanni Duro

The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.

Vaccine carrier

Hypoallergenic mosaic antigens assembled from naturally-occurring allergens are disclosed herein. Also disclosed are methods of making such hypoallergenic mosaic antigens, particularly those derived from plant allergens such as timothy grass pollen (Phl p 1 and Phl p 2) and birch pollen (Bet v 1). In a particularly preferred embodiment, the method of making the hypoallergenic mosaic antigen involves the steps of (a) cleaving a naturally-occurring allergen into at least two, preferably at least three non-overlapping peptide fragments and (b) recombining the peptide fragments such that the mosaic antigen includes all or substantially all of the amino acids of the original naturally-occurring allergen, though in a different order.

Hypallergenic mosaic antigens and methods of making same

The present invention relates to non-naturally occurring polypeptides derived from fish allergens such as parvalbumin Cyp c 1.01 from carp. The polypeptides display reduced allergenic activity and are useful as allergy vaccines for treatment of sensitized allergic patients and for prophylactic vaccination.

Hypoallergenic mutant polypeptides based on fish parvalbumin

The present invention relates to a novel allergen from timothy grass () pollen, Phl p11 as disclosed in SEQ ID NO:2, and use thereof as a reagent and in a diagnositic kit as well as for immunotherapy.

Allergen

Growing community of inventors

Vienna, Austria

Susanne Spitzauer