Celldex Therapeutics Limited

Kolltan Pharmaceuticals, Inc.

Susanne Radke

Joseph Schlessinger

Yaron R Hadari

Yoshihisa Suzuki

Elizabeth M Mandel-Bausch

Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.

Anti-KIT antibodies and uses thereof

Methods of treating by administering anti-kit antibodies

Polynucleotides encoding anti-KIT antibodies

Anti-kit antibodies

Growing community of inventors

Hamden, CT, United States of America

Susanne Radke