Michigan Biotechnology Institute

Mbi International

Susanne Kleff

Michael V Guettler

Jian Yi

Robert J Hanchar

Denise S Rumler

Sanchin Jadhav

Robert Hanchar

This invention provide processes for producing carboxylic acid product, along with useful salts. The carboxylic acid product that is produced according to this invention is preferably a C-Ccarboxylic acid. Among the salts produced in the process of the invention are ammonium salts.

Production of carboxylic acid and salt co-products

This invention is directed to methods of obtaining a high quantity of desired acid salt in a form that is relatively easy to recover. Particularly desired as a recovery product is an organic acid. A salt form of the desired organic acid is formed that is relatively high in concentration and that is relatively soluble in an aqueous medium. The method includes a step of fermenting a fermentable carbon source in the fermentation medium in the presence of a magnesium compound containing oxygen.

Fermentation method using a magnesium compound containing oxygen

Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinantthat has been transformed to express a Zwischenferment (Zwf) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.

Recombinant microorganisms for increased production of organic acids

Growing community of inventors

Okemos, MI, United States of America

Susanne Kleff