Merck Sharp + Dohme Corp.

Susannah Williams

Timothy Harrison

Ian Churcher

Martin Richard Teall

Alan John Nadin

Duncan Edward Shaw

Sonia Kerrad

Paul Joseph Oakley

Brian John Williams

Andrew Pate Owens

Kevin Dinnell

Jose Luis Castro Pineiro

Andrew Madin

Timothy Jason Sparey

Alexander Richard Guiblin

Joanne Thomson

Sonia Kerrard

Novel sulphones of formula I are disclosed:  The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Cyclohexyl sulphones

A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by &#x3b3;-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of &#x3b2;-amyloid, such as Alzheimer's disease 

Benzodiazepine derivatives as APP modulators

Compounds of formula I: wherein Arand Arare optionally substituted aryl or heteroaryl, L is a bond, &#x2550;CH&#x2014; or &#x2014;(CHR)&#x2014;, and X is SCN, SR, S(O)R, (CRR)SOR, SON(R), SONHCOR, SONHN(R), OSON(R, OS(O)N(R), OSONHCOR, COR, NHCOR, NHCOR, NHCON(R), NHSORor NHSON(R), inhibit the processing of APP by gamma secretase, and hence are useful in treatment of Alzheimer's disease.

Cyclohexyl sulphone derivatives as gamma-secretase inhibitors

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Compounds of formula I:inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.

Cyclohexyl sulphones as gamma-secretase inhibitors

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Basingstoke, United Kingdom

Susannah Williams