Aalto University

Cleandet Oy

Susanna Hällsten

Juha Koivisto

Tim Liedl

Yike Huang

Minh-Kha Nguyen

Jacky Loo

Anton Kuzyk

Pasi Karppinen

Eelis Mielonen

Jenni Inkinen

Evgenia Iakovleva

Riia Ranta

David Kocsis

The present invention is directed to a nanoscaled construct, said construct comprising or essentially consisting of a nucleic acid structure with reconfigurable or switchable features, and at least two separate metallic nanoparticles coupled with said nucleic acid structure, wherein said two separate nanoparticles are at an interchangeable angle to each other, wherein said nanoparticles provide high chirality and/or optical activity within the visible and near-infrared (NIR) spectrum from 400 to 800 nm generating a color for the construct, and wherein said construct has an absorption dissymmetry factor (g-factor) of over 10%. There is also provided a method for detecting an analyte in a sample, the method comprising steps of contacting a nanoscaled construct of the present disclosure specific to said analyte with a sample in a test assay, and detecting said analyte in said sample by optical means or by naked eye, wherein the presence of the analyte in said sample changes the color of said nanoscaled structure and the change of color in said assay confirms the presence of the analyte in said sample.

Colorimetric sensing with reconfigurable chiral plasmonic structures and a method for detecting analytes in samples using the same

Growing community of inventors

Espoo, Finland

Susanna Hällsten