Diadexus, Inc.

Susana Salceda

Yongming Sun

Herve Recipon

Robert Cafferkey

Shujath Ali

Chenghua Liu

Roberto A Macina

Leah R Turner

Ping Hu

Jason Pluta

The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating selected cancers including gynecologic cancers such as breast, ovarian, uterine and endometrial cancer and lung cancer.

Method of diagnosing, monitoring, staging, imaging and treating various cancers

The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating prostate cancer.

Method of diagnosing, monitoring, staging, imaging and treating prostate cancer

The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

Compositions and methods relating to ovarian specific genes and proteins

The present invention provides a new method for detecting, diagnosing, monitoring, staging and prognosticating prostate cancer.

Method of diagnosing, monitoring, and staging prostate cancer

The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating prostate cancer.

Diagnostic markers for breast cancer referred to herein breast cancer specific genes or BCSGs are provided. Also provided are methods for using BCSGs to detect, diagnose, monitor, stage, prognosticate, image and treat breast cancer. Antibodies which specifically bind BCSGs and methods of using these antibodies to image and treat breast cancer are also provided.

Method of diagnosing, monitoring, staging, imaging and treating breast cancer

The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

Compositions and methods relating to breast specific genes and proteins

The present invention provides polynucleotides and polypeptides which are diagnostic markers for mammary gland cancer. In addition, antibodies immunospecific for these markers are provided. Vectors, hosts cells and methods for producing these markers, as well as methods and tools for using these markers in detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating mammary gland cancer are also provided.

Compositions and methods of diagnosing, monitoring, staging, imaging and treating mammary gland cancer

The present invention provides a new method for detecting, diagnosing, monitoring, staging, and prognosticating breast cancer.

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San Jose, CA, United States of America

Susana Salceda