Isis Pharmaceuticals, Inc.

Susan Weinbach

Richard S Geary

Gregory E Hardee

Lloyd G Tillman

Mangaraju Gudipati

Araz A Raoof

David C Bibby

A pharmaceutical composition comprising an antisense oligonucleotide and a permeation enhancer that comprises a multi-carbon backbone having a functional group and also one or more side chains which have one or more carbon atoms and, optionally, one or more functional groups.

Antisense permeation enhancers

Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second population of carrier particles comprising a penetration enhancer and a delayed release coating or matrix. This penetration enhancer is released at a second location in the intestine downstream from the first location and enhances absorption of the drug when it reaches the second location.

Pulsatile release compositions and methods for enhanced intestinal oligonucleotide drug absorption

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San Diego, CA, United States of America

Susan Weinbach