Third Wave Technologies, Inc.

Susan S Wigdal

Jeff G Hall

Robert W Kwiatkowski, Jr

Andrea L Mast

Hon Ip

Christian Tor Bartholomay

Poonam Agarwal

Patrick Peterson

Molly Accola

Nancy Jarvis

Erin Dorn

Vincent Tevere

Hon S Ip

Laura Heisler

Molly A Accola

The present invention provides compositions and methods for the detection and characterization of mutations associated with non-syndromic hearing impairment. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of mutations in the Connexin 26, or gap junction beta 2, gene associated with non-syndromic hearing loss.

Connexin allele detection assays

The present invention provides compositions and methods for the detection and characterization of mutations associated with cystic fibrosis. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of mutations in the CFTR gene associated with cystic fibrosis. The present invention also provides compositions, methods and kits for screening sets of CFTR alleles in a single reaction container.

CFTR allele detection assays

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Madison, WI, United States of America

Susan S Wigdal