The Scripps Research Institute

Susan R Webb

Per A Peterson

Michael R Jackson

Lars Karlsson

Ola Winqvist

Ola Wingvist

The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.

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MHC class II antigen-presenting systems and methods for activatind CD4+T cells

The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4 T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.

MHC class II antigen-presenting systems and methods for activating CD4&plus; T cells

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Leucadia, CA, United States of America

Susan R Webb