Tetralogic Pharmaceuticals Corporation

Siga Technologies Inc.

Tetralogic Birinapant UK Ltd.

Medivir Ab

Wyeth

Viropharma Incorporated

Stephen M. Condon

Susan R. Rippin

Yijun Deng

Matthew G. Laporte

Susan R Rippin

Stephen M Condon

Matthew G Laporte

Thomas R Bailey

Robert Jordan

Dongcheng Dai

Christopher J Burns

Theodore John Nitz

Hao Feng

Ashis Kumar Saha

David J Rys

Thomas A Lessen

Thomas Faitg

John Swestock

Alfred Michael Del Vecchio

Jason A Reinhardt

Bheemashankar A Kulkarni

Charles W Blackledge

A SMAC mimetic and pharmaceutical compositions thereof and methods of use.

SMAC mimetic

SMAC Mimetic

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inhibitors, NSAIDs, taxanes and platinum containing compounds use broader language.

Dimeric IAP inhibitors

IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kof less than 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposed are also disclosed.

IAP binding compounds

Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

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SMAC mimetic for treating myelodysplastic syndromes

Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases

IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPB (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds have a Kof less than 0.1 micromolar. Methods of using these IAP binding molecules for therapeutic, diagnostic, and assay purposed are also disclosed.

Growing community of inventors

Wilmington, DE, United States of America

Susan R Rippin