Colorado State University Research Foundation

Able Planet, Inc.

Susan P James

Min Zhang

Guy Beauregard

David Alois Prawel

Rachael Kurkowski Oldinski

Ketul C Popat

Michael W Thompson

Michael L Peterson

Joan M Burleigh

Richard L Koch

Lakshmi Prasad Dasi

E Christopher Orton

Travis S Bailey

Jackson T Lewis

Harold Dean, Iv

Kyle Garrett Ordway

John Ordway, Legal Representative

Susan S Yonemura

Ariane Vartanian

Hieu Bui

Marcio H Forleo

Nicole R Lewis

Eric Monnet

Harold Dean Iv

Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.

Synthetic polymeric materials and devices thereof

The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.

Material comprising outer layer having entanglement of hydrophobic polymer host blended with anhydride functionalized hydrophobic polymer co-host and hydrophilic guest

Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.

Glycosaminoglycan and synthetic polymer materials for blood-contacting applications

The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention.

Polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer

Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.

Glycosaminoglycan and synthetic polymer material for blood-contacting applications

An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer.

Outer layer having entanglement of hydrophobic polymer host and hydrophilic polymer guest

Outer layer having entanglement of hydrophobic polymer host blended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest

An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer material having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host, or host blend, (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer with or without additional crosslinking of the host to the host.

Outer layer material having entanglement of hydrophobic polymer hostblended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest

A dynamic device for reducing functional mitral regurgitation is described. The device is disposed externally to the heart and effectively acts as a splint for reducing further dilation of the heart in patients diagnosed with cardiomyopathy, and for reducing tethering of the papillary muscle on the mitral valve. The device does not require cardiopulmonary bypass for its installation since it is attached to the outside of the left ventricle, thereby reducing surgical risk, and is not exposed to the patient's blood once installed, thereby reducing the risk of thromboembolic disease.

Remediation of functional cardiac mitral valve regurgitation

Pathological binaural phase time delay (PBTD) asynchrony is measured at a variety of frequencies and speech stimuli to develop a BPTD profile for a subject. A corrective device () is designed to apply clinical PBTD to compensate for the subject's pathological BPTD. An electronic device () is used to measure the subject's ability to comprehend words at a variety of relative time delays between ears to estimate the ideal overall relative time delay. The optimal relative phase shift at a variety of frequencies is also measured. An electronic device () may be used to correct the pathological BPTD by delaying sound in different frequency bands differently to the target ear, according to the BPTD profile, or a passive filtered earplug () may be used to correct smaller amounts of BPTD.

Apparatus and methods for mitigating impairments due to central auditory nervous system binaural phase-time asynchrony

A series of novel, melt- or mold-processable HA esters with varying aliphatic chain lengths are synthesized from silyl HA-quaternary (quat.) ammonium salt complex (preferably silyl HA-CTA, a silylated HA complex with cetyltrimethyl ammonium salt). Introduction of aliphatic acyl groups, preferably acid chlorides, to disrupt the strong HA intermolecular bonding, is done via acylation. Acylation takes place at the oxygen of the trimethylsilyloxy group &#x2014;O&#x2014;Si(CH)in the silyl HA-CTA by removal of trimethylsilyl groups therefrom. Optionally, crosslinking may be performed during the shaping/molding of the HA esters into a structure/device, or thereafter, if at all. Native HA can then be regenerated/recovered by saponification hydrolysis, removing acyl groups, &#x2014;CH(CH)CO, and the cetyltrimethyl ammonium salt groups, -CTA, from HA ester. The structure/device of a preselected shape (e.g., porous or solid, bulk structure or fibers) may become a component of an assembly, a product that is further processed, integrated into another component (e.g., laminated, adhered, assembled, further shaped, chemically-intermixed/intermingled), and so on.

Hyaluronan (HA) esterification via acylation technique for moldable devices

Pathological binaural phase time delay (BPTD) asynchrony is measured at a variety of frequencies and to speech stimuli to develop a BPTD profile for a subject. Then a corrective device () is designed to apply clinical BPTD to compensate for the subject's pathological BPTD. An electronic device () is used to measure the subject's ability to comprehend words at a variety of relative time delays between ears to estimate the ideal overall relative time delay. The optimal relative phase shift at a variety of frequencies is also measured. An electronic device () may be used to correct the pathological BPTD by delaying sound in different frequency bands differently to the target ear, according to the BPTD profile, or a passive filtered earplug () may be used to correct smaller amounts of BPTD.

Growing community of inventors

Bellvue, CO, United States of America

Susan P James