Duke University

Other

Susan M Ludeman

Michael O Colvin

Robert Storms

Clayton A Smith

Ines Batinic-Haberle

Ivan Spasojevic

Michael P Gamcsik

W Mark Saltzman

Wenbin Dang

O Michael Colvin

Robert W Storms

The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.

Method of activation of oxazaphosphorines

The present invention relates, in general, to stem cells, and in particular, to a method of isolating stem cells and to reagents suitable for use in such a method. The invention further relates to stem cell populations isolatable in accordance with the present method.

Method of isolating stem cells

Polymeric drug conjugates in controlled release matrices are provided which allow sustained concentrations of therapeutic agents within a treated area for a prolonged period. The polymeric drug conjugates hydrolytically degrade in the extracellular space in a controlled, pre-specified pattern, releasing active drug. The conjugates diffuse within the tissue reaching a greater distance from the matrix than free drug would, because of their reduced rate of clearance from the tissue via the capillary system.

Multipart drug delivery system

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Delmar, NY, United States of America

Susan M Ludeman