US Government As Represented by the Secretary of the Army

Susan L Welkos

Arthur M Friedlander

Peter M Pushko

Jonathan F Smith

Michael D Parker

John S Lee

George W Anderson, Jr

David G Heath

Bruce Ivins

Patricia Worsham

Joseph W Farchaus

Disclosed herein is a method of inducing an immunological response in a subject which comprises administering an immunogenic amount of a purified fusion protein comprising all or part of F1 antigen offused to the amino terminus of all of V antigen of, orto the subject.

Treatment methods using an F1-V plague vaccine

Disclosed herein is a composition comprising a purified fusion protein comprising all or part of F1 antigen offused to the amino terminus of all of V antigen of, orthat is isolated from its expression vector.

Recombinant F1-V plague vaccine

Using the nontoxic PA protein from, a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.

Anthrax vaccine

Using the nontoxic PA protein from , a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.

A method of making a vaccine for anthracis that inolves a bacterial expression system and production and use of protective antigen (PA) against . The PA immunogen is useful in a vaccine against human anthrax. The PA can be produced by an asporogenic organism which produces the desired antigen, which is then harvested from the supernatant.

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Frederick, MD, United States of America

Susan L Welkos