Dana-farber-cancer Institute Inc.

Harvard College

Susan Korsmeyer, Legal Representative

Stanley J Korsmeyer

Gregory Lawrence Verdine

Loren D Walensky

Emily H Y Cheng

James J D Hsieh

Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ('hydrocarbon stapling') moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.

Stabilized alpha helical peptides and uses thereof

A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.

Inhibitors of Taspase1 protease activity

Growing community of inventors

Weston, MA, United States of America

Susan Korsmeyer, Legal Representative