Novartis Ag

Novartis Vaccines & Diagnostics, Gmbh

Susan Kaufman

Hong Yang

Martin Sendzik

Weibo Wang

Savithri Ramurthy

James Clifford Sutton

Jiong Lan

Keith Bruce Pfister

Allan S Wagman

Simon C Ng

Mika Lindvall

Marion Wiesmann

Elizabeth J Mieuli

Anu Sharma

Victoria Sung

William Lenahan

Liana M Klivansky

Mika K Lindvall

William P Lenahan

Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling

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Lafayette, CA, United States of America

Susan Kaufman