Apeptico Forschung Und Entwicklung Gmbh

Susan Jane Tzotzos

Bernhard Fischer

Rudolf Lucas

Hendrik Fischer

Helmut Pietschmann

Waheed Shabbir

Anita Willam

Rosa Lemmens-Gruber

A method of conditioning/improving lung functions extracorporeally by treatment of a non-ischemic donor lung ex vivo with a cyclized compound of the amino acid sequence of formulaX-GQRETPEGAEAKPWY-X  I

Pharmaceutical composition comprising a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2 and use for extracorporeal lung treatment

A cyclic organic compound which comprises 16 amino acids or 17 amino acids and has no carboxyl group C-terminally and/or no amino group N-terminally. Optionally, one of the amino acids is a nonnatural amino acid. The ring closure is formed between a side chain of one amino acid and the C-terminus of another amino acid, or the ring closure is effected with the aid of a nonnatural amino acid. A process for producing and using the compound for regulating vectorial ion channels, for treating diseases associated with the lung function and for treating oedemas is provided.

Organic compound for the regulation of vectorial ion channels

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Vienna, Austria

Susan Jane Tzotzos