Merck + Co., Inc.

Susan J DeSolms

Otto W Woltersdorf, Jr

John J Baldwin

Edward J Cragoe, Jr

Joseph P Vacca

Steven D Young

Joel R Huff

Jonathan M Wiggins

Certain substituted hexahydroarylquinolizines and pharmaceutically acceptable salts thereof are peripherally selective .alpha..sub.2 -adrenoceptor antagonists. The compounds are adapted to be employed for the treatment of certain pathological disorders such as hypertension, diabetes, disorders involving platelet aggregation and the like without side effects attributable to effect on the central nervous system.

Substituted hexahydroarylquinolizines

The case involves novel heterocyclic substituted pyrazinoylguanidines and a process for preparing same. The heterocyclic pyrazinoylguanidines are eukalemic agents possessing diuretic and natriuretic properties.

Heterocyclic substituted pyrazinoylguanidines

The case involves novel pyrazinecarboxamide compounds and processes for preparing same. The pyrazinecarboxamides are eukalemic agents possessing diuretic and natriuretic properties.

Novel pyrazinecarboxamides and processes for preparing same

N-amidino-3,5-diamino-6-substituted-2-pyrazinecarboxamides and a process for their synthesis.

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Norristown, PA, United States of America

Susan J DeSolms