University of Massachusetts

US Government As Represented by the Secretary of the Army

Triton Biosystems, Inc.

Susan J Braunhut

Kenneth A Marx

Jayant Kumar

Ferdinando F Bruno

Lynne Ann Samuelson

Ramaswamy Nagarajan

Erik Schroeder Handy

Joel M Therrien

Diane L Ellis-Busby

Allan Foreman

Douglas Ulen Gwost

Robert Ivkov

Subhalakshmi Nagarajan

Donna McIntosh

Berk Akinci

Anne Rugh

Blair Ardman

Abiche H Dewilde

Klaudia Foley

Tiean Zhou

In an embodiment, a system includes a plurality of sensor devices contained in a plurality of wells contained in a well-plate assembly. The sensor devices are used in a plurality of oscillators. Each oscillator generates a frequency and a resistance based on a quality of living biological cells contained in a corresponding well. The quality may include, for example, surface coupled mass, density, viscosity, and/or viscoelasticity of the living biological cells. The system also includes logic for measuring a resonant frequency and motional resistance associated with each sensor device and logic for processing the measured resonant frequency and motional resistance. Moreover, the system includes logic for displaying one or more graphs showing one or more characteristics of the living biological cells contained in the wells.

Multi-well quartz crystal microbalance mass and viscoelastic sensor

A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.

Synthesis of oligo/poly(catechins) and methods of use

Selective whole cell QCM biosensors are disclosed. Also disclosed are methods of making and using such whole cell QCM biosensors, e.g., to screen drugs and diagnose diseases.

Selective whole cell quartz crystal microbalance biosensors

Disclosed are therapeutic methods for the treatment of disease material involving administration of a thermotherapeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods of administering the thermotherapeutic magnetic material composition. The thermotherapeutic methods may be used where the predetermined target is associated with diseases, such as cancer, diseases of the immune system, and pathogen-borne diseases, and undesirable targets, such as toxins, reactions associated with organ transplants, hormone-related diseases, and non-cancerous diseased cells or tissue.

Thermotherapy via targeted delivery of nanoscale magnetic particles

Growing community of inventors

Wellesley, MA, United States of America

Susan J Braunhut