Scipher Medicine Corporation

Susan Ghiassian

Keith J Johnson

Nancy J Schoenbrunner

Viatcheslav R Akmaev

Theodore R Mellors

Asher Ameli

Marc Santolini

Methods of treating a subject suffering from an autoimmune disease, disorder, or condition with an alternative to anti-TNF therapy.

Methods of treating a subject with an alternative to anti-TNF therapy

Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides a method of treating subjects suffering from an autoimmune disorder, the method comprising administering an alternative to anti-TNF therapy to subjects who have been determined to be non-responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy.

Methods of treating a subject suffering from rheumatoid arthritis with alternative to anti-TNF therapy based in part on a trained machine learning classifier

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Boston, MA, United States of America

Susan Ghiassian