Biogen Ma Inc.

Biogen Idec Ma Inc.

Susan Foley

Justin Andrew Caravella

Scott Glaser

Brian Miller

Bruno Domon

Michele Sanicola-Nadel

Kevin P Williams

Susan Gail Schiffer

Tigran Aivazian

Xiaoping Hronowski

Brian Robert Miller

Tigran Dikran Aivazian

The invention is based, at least in part, on the finding that linker peptides which lack the amino acid sequence GSG reduce or eliminate the addition of posttranslational modifications to the polypeptides which comprise them. More specifically, the novel linker peptides disclosed herein reduce the ability of enzymes to link carbohydrate adducts to polypeptides comprising these linker peptides, e.g., reduce the ability of xylosyltransferase to link xylose to polypeptides. These novel linker peptides, molecules comprising same, and methods of their use are described.

Linker peptides and polypeptides comprising same

The present invention is based on the discovery that CRIPTO mutants each comprising at least one amino acid substitution from a CRIPTO polypeptide demonstrate tumor blocking activity.

Cripto mutant and uses thereof

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Milford, MA, United States of America

Susan Foley