N.v. Organon

Neurosearch A/s

Pharmacopeia Inc.

Merck Sharp + Dohme B.v.

Pharmacopeia Drug Discovery, Inc.

Susan Elizabeth Napier

Michael H Ohlmeyer

Jeffrey John Letourneau

Patrick Anthony Jokiel

Koc-Kan Ho

Christopher Mark Riviello

Irina Neagu

John Richard Morphy

Jui-Hsiang Chan

Matilda Jane Bingham

Lene Teuber

Paul David Ratcliffe

Naheed Mirza

Andrew Cooke

Frank Wätjen

Niall Morton Hamilton

Olaf Nimz

Jurgen Schulz

Fiona Jeremiah

Duncan Robert McArthur

Mark Huggett

Neil Andrew Dunbar

Morag Ann MacCall Easson

Koc-Kan Hoc

Yasuko Kiyoi

Margaret Jean Huggett

Jeffrey Letourneau

Duncan Robert Mcarthur

Jeremiah Fiona

Schulz Jurgen

Jui Hsiang Chan

Disclosed herein are 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivative of formula I, or pharmaceutically acceptable salts or solvates thereof wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivatives according to the present invention and their use in therapy.

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The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

9-azabicyclo[3.3.1]nonane derivatives

Disclosed herein are quinazolinone or isoquinolinone derivatives of formula I, or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising quinazolinone or isoquinolinone according to the present invention and its use in therapy.

Quinazolinone and isoquinolinone acetamide derivatives

The present invention relates to 2-(4-oxo4H-quinazolin-3-yl) acetamicle derivatives of formula (I), and to their use as vasopressin V3 antagonists, particularly for the treatment of depression. 

2-(4-oxo-4H-quinazolin-3-yl)acetamides and their use as vasopressin V3 antagonists

This invention relates to novel 1,5,7-trisubstituted benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAreceptor complex.

The present invention relates to a 8-azabicyclo[3.2.1] octane derivative of Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt thereof or solvate thereof. The present invention also relates to a pharmaceutical composition comprising an 8-azabicyclo [-3.2.1] octane derivative in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of the 8-azabicyclo[3.2.1] octane derivative in therapy.

8-azabicyclo[3.2.1]octane derivatives

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Newhouse, United Kingdom

Susan Elizabeth Napier