Abbvie Inc.

Abbvie Biotherapeutics Inc.

Susan Elizabeth Morgan-Lappe

Jonathan A Hickson

Yingchun Li

Chung-Ming Hsieh

Jijie Gu

Kurt C Gish

Lorenzo Benatuil

Yuliya Kutskova

Erwin R Boghaert

Maria Harris

James W Purcell

Ming-Jiu Chen

Tariq Ghayur

Jieyi Wang

Randy Bell

Marvin Robert Leanna

Edward B Reilly

Shweta Singh

Zhihong Liu

Gillian A Kingsbury

Andrew C Phillips

Junjian Liu

Hua Ying

Jennifer Hope Richardson

Sahana Bose

Suzanne M Norvell

Laura Patterson Serwer

Jonathan Alexander Terrett

Sherry L Ralston

Ilaria Badagnani

Tracy Henriques

The present disclosure provides antibodies, antibody binding fragments, and antibody drug conjugates that bind human LRRC15, their methods of making, and their uses to treat patients having cancer.

Anti-huLRRC15 antibody drug conjugates and methods for their use

Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.

Therapeutic DLL4 binding proteins

DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Dual variable domain immunoglobulins and uses thereof

Growing community of inventors

Riverwoods, IL, United States of America

Susan Elizabeth Morgan-Lappe