Medtronic Ardian Luxembourg S.a.r.l.

Medtronic Ireland Manufacturing Unlimited Company

Medtronic Adrian Luxembourg S.a.r.l.

Susan Edwards

Ayala Hezi-Yamit

Carol M Sullivan

Christopher W Storment

Rudy Beasley

Michele Lee Silver

Stefan Stoyanov Tunev

Lori Garcia

Joseph A Traina

Carol Sullivan

Stefan Tunev

Provided herein are methods, systems, and devices for increasing heat shock protein expression and treating conditions for which increased heat shock protein expression is expected to be beneficial using thermal ablation.

Methods and devices for localized disease treatment by ablation

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers. One aspect includes a comparison of baseline and post-modulation levels of one or more biomarkers in bodily fluid that have each been collected from a human subject at a relevant time, and that may be used to assess the neuromodulation efficacy. The post-neuromodulation levels for the one or more biomarkers may be collected from the human subject within about 5 minutes to about 14 days post-neuromodulation.

Monitoring of neuromodulation using biomarkers

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.

Devices and associated methods for monitoring of neuromodulation using biomarkers

Provided herein are methods, systems, and devices for increasing IL-10 expression, inhibiting inflammation, and treating inflammatory conditions using thermal ablation.

Methods and devices for localized inhibition of inflammation by ablation

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on detecting changes in the level or activity of one or more target biomarkers associated with neuromodulation, as well as methods and processes of performing neuromodulation that incorporate monitoring of neuromodulation efficacy based on changes in level or activity of one or more target biomarkers.

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Santa Rosa, CA, United States of America

Susan Edwards