Biogen, Incorporated

Susan E Goelz

Roy R Lobb

Catherine A Hession

Christopher D Benjamin

Margaret D Rosa

Laurelee Osborn

R Blake Pepinsky

Richard L Cate

E Pingchang Chow

VCAM fusion proteins capable of binding to VLA4, and DNA molecules coding on these fusions.

VCAM fusion proteins and DNA coding therefor

VCAM1 polypeptides and VCAM11/ICAM fusion proteins are disclosed.

Vascular cell adhesion molecule (VCAM) polypeptides

A IFN-.beta. mutein in which phe (F), tyr (Y), trp (W) or his (H) is substituted for val (V) at position 101, when numbered in accordance with wild type IFN-.beta., DNA sequences encoding these IFN-.beta. muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression control sequences and capable of inducing expression of an IFN-.beta. mutein, hosts transformed with those recombinant DNA molecules, pharmaceutical compositions containing IFN-.beta. muteins and methods for treating viral infections, cancer or tumors, undesired cell proliferation, or for immunomodulation.

Muteins of IFN-.beta.

A IFN-.beta. mutein in which phe (F), tyr (Y), trp (W) or his (H) is substituted for val (V) at position 101, when numbered in accordance with wild type IFN-.beta., DNA sequences encoding these IFN-.beta. muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression control sequences and capable of inducing expression of an IFN-.beta. mutein, hosts transformed with those recombinant DNA molecules, pharmaceutical compositions containing IFN-.beta. muteins and methods of using those compositions to treat viral infections, cancer or tumors or for immunomodulation.

DNA sequences encoding endothelial cell-leukocyte adhesion molecules ELAMs, methods for producing such molecules, and ELAMs (including the specific molecules ELAM1 and VLAM1 and 1b) essentially free of normally associated animal proteins are disclosed. DNA sequences encoding molecules involved in leukocyte adhesion (MILAs), methods for producing such molecules and MILAs (including the specific molecule, CDX) essentially free of normally associated animal proteins are also disclosed. Antibody preparations which are reactive for MILAs and also disclosed. Methods for identifying molecules which inhibit binding of leukocytes to endothelial cells, methods for inhibiting leukocyte binding to endothelial cells, and methods for detecting acute inflammation are disclosed.

Endothelial cell-leukocyte adhesion molecules (ELAMs) and molecules

DNA sequences encoding vascular cell adhesion molecules 1 and 1b ('VCAM1' and 'VCAM1B'), recombinant DNA molecules comprising those sequences, and unicellular hosts transformed with those recombinant DNA molecules.

DNA sequences encoding vascular cell adhesion molecules (VCAMS)

Monoclonal antibodies against CDX, a leukocyte cell surface molecule that is a ligand of ELAM 1, and methods for producing them. Monoclonal antibody SGB.sub.3 B.sub.4 and monoclonal antibodies reactive to the same epitope. These monoclonal antibodies inhibit leukocyte-endothelial cell adhesion.

Growing community of inventors

Winchester, MA, United States of America

Susan E Goelz