Koninklijke Philips Corporation N.V.

Susan E Beiter

Patrick G Rafter

A therapeutic agent is incorporated into microbubbles of a contrast agent, and the microbubbles containing the therapeutic agent are delivered to a region of interest in a patient. An ultrasound image of the region of interest is generated by an ultrasound imaging system, and ultrasound energy for destroying the microbubbles of the contrast agent is transmitted to the region of interest. Parameter data that is representative of activation of the therapeutic agent in the region of interest is acquired, and a parameter display is generated. One or more parameters of the ultrasound energy applied to the region of interest for activating the therapeutic agent may be adjusted, either manually based on the parameter display or automatically based on acquired parameter data. In one embodiment, the parameter display is indicative of a parameter associated with the ultrasound energy transmitted to the region of interest. In another embodiment, the parameter data is acquired by detecting destruction of microbubbles of the contrast agent.

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Ayer, MA, United States of America

Susan E Beiter