Pfizer Corporation

Verastem, Inc.

Susan D La Greca

Joseph P Lyssikatos

Michael John Munchhof

Christopher Scott Jones

Lawrence Alan Reiter

Qifang Li

Michael Luzzio

John Charles Kath

Bingwei Vera Yang

Jinshan Michael Chen

Matthew Arnold Marx

Joel Thomas Arcari

Matthew David Wessel

Nandini Chaturbhai Patel

The present invention relates to salts, solvates and substoichiometric solvates of N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide. The invention also provides pharmaceutical compositions comprising such complexes, as well as methods of treating abnormal cell growth by administering the complexes of the invention.

Pyrimidine derivatives for the treatment of abnormal cell growth

The present invention relates to a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, X, m, and n are as defined herein. Such novel benzamidazole derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Benzimidazole derivatives

The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein Q, A, L, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

Pyrrolopyrimidine derivatives

Alkynyl-substituted quinolin-2-one derivatives useful as anticancer agents

Quinolin-2-one derivatives useful as anticancer agents

The present invention relates to compounds of formula 1

The present invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, and R.sup.11 are as defined herein. The above compounds of formula 1 are useful in the treatment of hyperproliferative disorders, such as cancer, in mammals. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering the compounds of formula 1 to a mammal requiring such treatment.

Alkynyl-substituted quinolin-2-one derivatives useful as anticancer

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Old Lyme, CT, United States of America

Susan D La Greca