Epigenomics Ag

Susan Cottrell

Reimo Tetzner

Fabian Model

Ralf Lesche

Dimo Dietrich

Juergen Distler

Andrew Z Sledziewski

Xiaoling Song

Sabine Maier

Peter Adorjan

Jürgen Distler

Matthias Burger

Theo Devos

Theo De Vos

J Kevin Day

Andrew Morotti

Su Yamamura

Carolina Haefliger

Sharon Dekker

Yreka Ocampo

Thomas L Skillman

Gunter Weiss

Suzanne Mooney

Andrew M Morotti

Kevin Day

Kevin J Day

Catherine Lofton-Day

Jeffrey G Thomas

Provided are methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders by analysis of one or more of the genes Versican, TPEF, H-Cadherin, Calcitonin, and EYA4. Further provided are novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said genes as well as methods, assays and kits thereof.

Method and nucleic acids for the analysis of colon cell proliferative disorders

The following application provides methods and nucleic acids for the detection of and/or differentiation between prostate cell proliferative disorders. This is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.

Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders

The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders as well as therapy thereof by analysis of the gene EYA4 and its promoter and regulatory sequences. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said gene as well as methods, assays and kits thereof.

Method and nucleic acids for the analysis of colorectal cell proliferative disorders

Described is a method for methylation detection in a DNA sample. An isolated genomic DNA sample is treated in a manner capable of distinguishing methylated from unmethylated cytosine bases. The pretreated DNA is amplified using at least one oligonucleotide primer, a polymerase and a set of nucleotides of which at least one is labeled with a first type of label. A sequence-specific oligonucleotide probe, marked with a second type of label, hybridizes to the amplification product and a FRET reaction occurs if a labeled oligonucleotide is present in close proximity in the amplification product. The method determines the level of methylation of a sample by measuring the extent of fluorescence resonance energy transfer (FRET) between the donor and acceptor fluorophore.

Quantitative methylation detection in DNA samples

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Seattle, WA, United States of America

Susan Cottrell