Wyeth

Susan Christman Croce

Eugene John Trybulski

Amedeo A Failli

Hassan Mahmoud Elokdah

Thomas Joseph Commons

David LeRoy Crandall

Gary Paul Stack

Arthur Attilio Santilli

Dominick Anthony Quagliato

Gavin David Heffernan

Dahui Zhou

Deborah Ann Evrard

Patrick Michael Andrae

Richard Dale Coghlan

Emily S Shen

Richard Page Woodworth

Aranapakam Madumbai Venkatesan

This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2). 

Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists

The present invention relates generally to substituted biphenyloxy acids (such as 4'-aryl-amido-biphenyl-4(3)-yloxy-acids and 4&#x2032;-aryl-amidomethyl-biphenyl-4(3)-yloxy-acids) and methods of using them, for example, as PAI-1 inhibitors.

Biphenyloxy-acids

Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans

6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)

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Lambertville, NJ, United States of America

Susan Christman Croce