The Procter Gamble Company

Susan Baldwin

Scott Edward Osborne

Stephen Worth Hendrix

Mauricio Odio

Gretchen Louise Elder

Bruce Ernest Tepper

Laura Graves Spalding Van Rijswijck

Michelle Denise Roseman

Kevin Eugene Grandison

A method for determining the relative benefits of products which affect animal epithelial tissue is provided. Also provided is a method for evaluating quantitative changes on one or more affected surfaces of epithelial tissue of a subject caused by a test product.

Methods for determining the relative benefits and/or evaluating quantitative changes of products on epithelial tissue

The present invention relates to a method comprising subjecting a test site of a responsive system to a primary challenge; subjecting the same test site to a secondary challenge, wherein the secondary challenge is designed to enhance and/or prolong a response of the responsive system to the primary challenge, without confounding the response nor altering the mechanism by which the primary challenge elicits a response from the responsive system; and assessing the response subsequent to the secondary challenge. The methods claimed herein also preferably comprise the additional step(s) of subjecting test site(s) to one or more pre-challenge intervention(s) and/or post-challenge intervention(s) and/or concurrent-challenge intervention(s). The methods of the present invention are also useful in a study design, also claimed herein, wherein the study comprises the steps of the method outlined above in addition to comprising the steps of creating one or more controls selected from the group consisting of negative controls, primary controls, secondary controls, positive controls, and mixtures thereof. The use of the novel methods described herein often significantly shorten the duration of and/or number of subjects needed for studies aimed at understanding the etiology of a disease and/or the ability of a intervention or challenge to prevent, cure, heal, and/or reduce and/or induce damage or injury to a responsive system.

Method to enhance and/or prolong the effects of a primary challenge to a responsive system with a secondary challenge

The present invention relates a method for improving skin condition by repeatedly applying lotion-treated absorbent articles to a wearer. When applied with sufficient frequency, the skin in the area covered by lotion-treated absorbent articles shows improvement in skin smoothness, relative to skin covered by untreated absorbent articles that do not comprise a skin care composition. The present invention also relates to methods for assessing skin smoothness in the area covered by an absorbent article.

Method for improving skin condition

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Cincinnati, OH, United States of America

Susan Baldwin