Rayzebio, Inc.

Qed Therapeutics, Inc.

Susan Arangio

Gang Chen

Daniel Daeik Kim

Matthew Moran

Ken Song

Gang Li

Riccardo Panicucci

Craig Berman

Daniel Mulreany

Michael Howland

Michael Monteith

Carl Dambkowski

Provided herein are methods of treating advanced or metastatic cholangiocarcinoma in a patient by administering to the patient infigratinib or a pharmaceutically acceptable salt thereof, wherein the patient has progression of the cholangiocarcinoma after previous administration of another therapy.

Methods of treating cholangiocarcinoma

Provided herein are radiopharmaceutical compositions and uses thereof. The radiopharmaceutical compositions can comprise one or more stabilizing agents, an aqueous vehicle, and a conjugate that comprises a targeting ligand and a radionuclide bound to a metal chelator. The targeting ligand can be a small molecule compound or a peptide such as a monocyclic peptide. The targeting ligand can be configured to bind with a tumor target. The stabilizing agent can comprise a radiolysis stabilizer, a free metal chelator, and/or a pH stabilizer. Further provided herein are methods of preparing the radiopharmaceutical compositions and methods of treating cancer by administering the described radiopharmaceutical compositions.

Stabilized compositions of radionuclides and uses thereof

Growing community of inventors

Los Altos, CA, United States of America

Susan Arangio