Cancer Research Campaign Technology Limited

Susan A Beck

The use of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid or EPA, preferably substantially free of any other polyunsaturated fatty acids, is disclosed for making up medical preparations or compositions for the treatment of cachexia by inhibiting lipolytic activity of biologically active lipolytic agents present in body fluids and the activity of the enzyme guanidinobenzoatase, as well as for reducing abnormal cAMP levels in cells of adipose tissue in mammals, produced by lipolytic or fat mobilizing substances.

Eicosapentaenoic acid used to treat cachexia

A biologically active lipolytic factor having an average molecular weight substantially less than 5000 daltons and comprising active molecular species having molecular weights of about 3000 daltons, 1500 daltons and 700-800 daltons is disclosed. The factor can be isolated, using chromatographic methods, from cachexia-inducing tumors, cultures of tissue cells of cachexia-inducing tumors especially cultures of a MAC16 tumor cell line, or from body fluids such as serum or urine of mammals bearing cachexia-inducing tumors. Cancer diagnostic applications in relation to human individuals are described as well as uses for screening and identifying potential anti-cachetic and/or antitumor therapeutic agents.

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Willenhall, United Kingdom

Susan A Beck