Council of Scientific and Industrial Research

Other

Surrinder Koul

Subhash Chandra Taneja

Ghulam Nabi Qazi

Jawahir Lal Koul

Sukhdev Swami Handa

Inshad Ali Khan

Rakesh Kamal Johri

Vijeshwar Verma

Subhash Chander Sharma

Ashwani Kumar

Ashok Kumar Tikoo

Pankaj Gupta

Anita Khosa

Zahid Mehmood Mirza

Monika Pandita

Beenu Moza

Vijay Kumar Sethi

Samar Singh Andotra

Kanaya Lal Dhar

Naveen Anand

Munish Kapoor

Rattan Lal Sharma

Shubash Chandra Taneja

Rajinder Parshad

Ravi Ji Kotru

The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2 (E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

Aromatic amides as potentiators of bioefficacy of anti-infective drugs

The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not add to any nutritional value but the synthesised compounds can possess useful pharmacological properties which is expected to find application in new test models for the development of anti-inflammatory drugs, bioavailability enhancers and for the study of hepatic drug metabolising mechanism; also relates to a process for preparing the said compounds.

Substituted aryl alkenoic acid heterocyclic amides

The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two enantiomers of trans alkyl phenylglycidate i.e. alkyl(2S,3R)-phenylglycidate and alkyl(2R,3S)-phenylglycidate of formulae 7 and 8 respectively 

Stereoselective chemoenzymatic process for the preparation of optically enriched phenylglycidates as precursors of taxol side chain

The present invention relates to a process for the systhesis of optically enriched dextro- and laevo-rotatory isomers of rose oxide from racemic citronellol. The invention particularly relates to the preparation of optically enriched (&minus;)-(2 S, 4 R)-rose oxide and its isomer (&plus;)-(2 R, 4 S)-rose oxide torn racemic citronellol.

Chemo-enzymatic synthesis of optically enriched rose-oxides

This invention discloses a process for the use of a novel organism belonging to the genus Trichosporon sp. as whole wet or dry cell culture or cell free extract or crude enzyme or pure isolated enzyme The strain of Trichosporon sp. used in the process is designated as RRLY-15 and has been deposited in Deutsche Sammlung von Mikroorganismen und Zellekulturen GmbH (DSMZ). The invention also discloses the preparation of S(&plus;)-6-methoxy-2-naphthalene acetic acid (naproxen) of formula (2) through enantioselective hydrolysis of a racemic mixture of alkyl esters of (&plusmn;)-6-methoxy-&agr;-methyl-2-naphthalene acetic acid of formula (1) where R represents &mdash;CH,,&mdash;C,H,,&mdash;C,H,,&mdash;C,H,and the like and S(&plus;)- Naproxen is a medicinally important non steroidal anti-inflammatory drug.

Trichosporon sp RRLY-15 (DSM 11829) and its use to prepare S(&plus;)-6-methoxy-methyl-2-naphthalene acetic acid

Growing community of inventors

Jammu, India

Surrinder Koul