Genentech, Inc.

Chiron Corporation

F. Hoffmann-la Roche Ag

Surinder Kaur

Keyang Xu

Ola Saad

Verena D Huebner

Gavin D Dollinger

Martine Darwish

Dian Su

Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.

Bioanalytical analysis of site-specific antibody drug conjugates

Methods are disclosed to detect, characterize, measure, and quantitate human and humanized antibodies, and their conjugates, present in pre-clinical animal biological samples, including plasma/serum and tissue samples.

Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides

Methods to detect, characterize, and quantitate biological samples after administration of antibody conjugates, antibody-drug conjugates of Formula I, antibodies, and fragments and metabolites thereof, by immunoaffinity bead separation, chromatography, and mass spectrometry are disclosed;Ab-(L-D)&#x2003;&#x2003;I

Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry

Compounds are quickly selected from a combinatorial library by contacting the library with a target (e.g., receptor), separating non-binding compounds from compound-target complexes, and analyzing the complexes or eluted compound by mass spectroscopy. SAR information is obtained by performing this selection at two or more different ratios of compound to target.

Growing community of inventors

Lafayette, CA, United States of America

Surinder Kaur