Purdue Research Foundation

The United States of America, As Represented by the Secretary, Department of Health and Human Services

University of Saskatchewan

Suresh Kumar Mittal

Lorne A Babiuk

Frank L Graham

Jacqueline M Katz

Ludvik Prevec

Suryaprakash Sambhara

Mary Hoelscher

Dinesh S Bangari

Mary Centers For Disease Control And Prevention Hoelscher

Jacqueline Centers For Disease Control And Prevention Katz

Suryaprakash Centers For Disease Control And Prevention Sambhara

Disclosed herein a unique cell line system to generate a novel bovine adenovirus vector that provides more gene insertion capabilities and better immunogenicity for inserted antigens. The unique cell line is used for generating and growing of the new adenovirus vectors for gene delivery or recombinant vaccine production.

Adenoviral vector system for gene delivery

The present disclosure provides compositions and methods for eliciting an immune response against avian or pandemic influenza. The compositions include adenovirus vectors comprising avian influenza antigens, recombinant adenovirus and immunogenic compositions comprising such recombinant vectors and adenovirus. Methods for eliciting an immune response against avian or pandemic influenza involving administering such adenovirus vectors or recombinant adenovirus are also provided.

Vaccine against pandemic strains of influenza viruses

The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and novel recombinant mammalian cell lines stably transformed with BAV E1 sequences, and therefore, express E1 gene products capable of allowing replication therein of a bovine adenovirus having an E1 deletion replaced by a heterologous nucleotide sequence encoding a foreign gene or fragment thereof and their use in production of (antigenic) polypeptides or fragments thereof for the purpose of live recombinant virus or subunit vaccine or for other therapies.

Recombinant protein production in bovine adenovirus expression vector system

Growing community of inventors

West Lafayette, IN, United States of America

Suresh Kumar Mittal